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P75 Involved in the Ubiquitination of α-synuclein in ...

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NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

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This process follows four principal steps in one continuous integrated loop, comprising four fixed bed reactors in a series in which a syngas is converted to synthetic fuels. The steps for producing high-octane synthetic gasoline are as follows: Methanol Synthesis: Syngas is fed to Reactor 1, the first of four reactors, which converts most of the syngas to methanol when passing through the ...

NEDD4-mediated HSF1 degradation underlies α ...

On the contrary, GFP-α-syn A53T expression was increased by exogenous ubiquitin overexpression, consistent with a positive role of HSF1 in α-syn clearance (Fig. 6). α-Syn-induced HSF1 degradation is mediated by the E3 ligase NEDD4

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Modular PROTAC Design for the Degradation of Oncogenic BCR ...

By recruiting E3 ubiquitin ligase to target proteins through target-specific ligands, a broad range of target proteins that are dysregulated in cells have been degraded [6][7] [8] [9][10][11][12 ...

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